pISSN : 2383-6415   eISSN : 2383-6423

Histological changes on the renal glomeruli by the Streptozotocin and Alloxan-induced diabetic mouse



INFORMATION : page. 20~33 / 2000 Vol.2 No.1


The author was used for the ICR mouse and induced diabetes with the streptozotocin(50mg/kg) and alloxan(40mg/kg). After the testing and the identifying the diabetes, the histological changes of the glomerulus, blood test for the values of blood sugar, and urine test for the values of urine protein were investigated. The results are as follows : 1. The values of high blood sugar appeared from the 2 group were about 378 mg/㎗ ~ 709mg/㎗, in the treated groups with the streptozotocin and alloxan. The glycosuria were obviously continued from the 2 weeks to the 12 weeks of the streptozotocin and the alloxan treated groups and the proteinuria was ± ~ + in the 4 weeks and 8 weeks of streptozotocin treated group and were + in all the 12 weeks. The ketonuria were generally negative. 2. In the view of the light microscope, there was no significant histological changes until the 8 weeks. However, in the 12 weeks group treated with the streptozotocin, the mesangial matrix of glomerulus increased Bowman's capsules adhered to each other and changed them to the crescence shapes because of increasing the exothelial cells.

Keyword :

신사구체,streptozotocin and alloxan,Mouse,Glomerulus


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