INFORMATION : page. 141~150 / 2017 Vol.19 No.3
노화과정은 활성산소(reactive oxygen species, ROS)와 우리 체내 항산화 능력 간의 불균형으로 인한 산화스트레스(oxidative stress)와 밀접한 관련이 있는 것으로 알려져 있다. 산화스트레스는 심혈관계 질환, 호흡기, 근골격계 질환 같은 노인성 질환과 수명에 영향을 미친다[1,2]. 산화스트레스는 다양한 요인에 의해 발생하는 것으로 보고되었으며[1,2], 그 중 호모시스테인은 산화과정을 통해 동맥혈관에 급격한 산화스트레스를 유발하여 동맥경화증의 독립적인 위험인자로 알려져 있다.
Purpose: The purpose of this study was to investigate the effects of the Korean Dietary Approaches to Stop Hypertension (DASH) education program on oxidative stress, antioxidant capacity, and serum homocysteine (Hcy) level in elderly Korean women. Methods: This was a quasi-experimental study employing non-equivalent control group pretest-posttest design. The DASH group (n=27) underwent the DASH education program for 12 weeks, whereas the control group (n=21) was provided one education session. The survey was conducted before and after the intervention period. Results: In DASH group, monounsaturated fatty acid (MUFA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) intakes significantly increased after the intervention as compared to prior to the intervention. No significant differences were found in the control group. After the intervention, thiobarbituric acid reactive substance (TBARS) and Hcy levels significantly decreased in the DASH group but not in the control group. Conclusion: The DASH education program was effective in reducing oxidative stress and Hcy levels in elderly Korean women.
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