pISSN : 2383-6415   eISSN : 2383-6423

Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant


Kyoungah Kang 

INFORMATION : page. 341~347 / 2015 Vol.17 No.4


Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and100 μg/mL). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1β, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-1β, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of PGE2 expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.

Keyword :

Anti-inflammation,Chrysanthemum indicum,RAW 264.7 cell


Journal Archive

19 Volumes, 4 Issues, 433 Articles

show all

Tag Cloud

교육 신뢰도 Rhinitis capsaicin 노래부르기 프로그램 갱년기 증상

Korean Society of Biological Nursing Science (Stay Connected)
Department of Clinical Nursing, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, KR 05505, Republic of Korea
Tel : +82-2-3010-5311 (Contact JKBNS Customer care: bionursing@naver.com) http://www.bionursing.or.kr/
Copyright JKBNS. All Rights Reserved.
Design by Hakjisa Pub.